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低强度脉冲超声波促进骨折修复的作用及其机制 被引量：2

Effects of low intensity pulsed ultrasound in accelerating the healing of fractures and its mechanism
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摘要 低强度脉冲超声波(Lowintensitypulsedultrasound,LIPU)是一种加速骨折修复,促进骨折愈合的物理疗法。LIPU是一种非侵入性机械能,经皮传递后可在生物器官内产生高频率的声波。1952年意大利学者首先报道了LIPU可加速兔桡骨骨折愈合,随后Heckman和Kris-tiansen等学者关于LIPU促进人胫骨和桡骨远端骨折的报道不仅促使美国FDA批准LIPU的临床应用,同时带来LIPU在骨折愈合修复领域应用和研究的热潮。综述LIPU在新鲜骨折,骨折延迟愈合和不愈合等骨科常见病物理治疗中的应用现状,并从骨折修复相关细胞内生物信号的改变,软骨内化骨早期出现以及加强骨重建修复等角度探讨了LIPU促进骨折愈合修复的可能作用机制。
作者 赵咏芳 邝適存 郭霞 郑振耀
机构地区 香港理工大学康复治疗科学系 香港中文大学矫形外科学系
出处 《中国临床康复》 CSCD 2004年第14期2722-2724,共3页 Chinese Journal of Clinical Rehabilitation
基金 香港研究资助局角逐拨款资助项目(PolyU5271/02M)
关键词 骨折愈合 软骨 骨重建
分类号 R683 [医药卫生—骨科学]
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参考文献27

  • 1Rubin C. Bolander M, Ryaby JP. et al. The use of low-intensity ultrasound to accelerate the healing of fractures. J Bone Joint Surg Am 2001; 83A:259-70
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  • 3Azuma Y. Ito M, Harada Y, et al. Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus. J Bone Miner Res 2001; 16:671-80
  • 4Warden SJ, Favaloro JM, Bennell KL, et al. Low-intensity pulsed ultrasound stimulates a bone-forming response in UMR-106 cells. Biochem Biophys Res Commun 2001; 286:443-50
  • 5Yang KH, Parvizi J, Wang SJ, et al. Exposure to low-intensity ultrasound increases aggrecan gene expression in a rat femur fracture model. J Orthop Res 1996; 14:802-9
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  • 8Kristiansen TK, Ryaby JP, McCabe J, et al. Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter,prospective, randomized, double-blinded, placebo-controlled study. J Bone Joint Surg Am 1997; 79:96
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二级参考文献1

共引文献20

同被引文献41

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中国临床康复
2004年 第14期

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