乙型肝炎表面抗原及抗体同时阳性特殊模式的临床流行病调查分析

The clinical and epidemic inquisition analysis of both positive mode of HBsAg and HBsAb

目的 了解乙型肝炎表面抗原及抗体同时阳性患者的临床流行病特点。方法 应用ELISA方法对乙型肝炎感染者HBV标志物进行初筛后 ,对乙肝表面抗原及抗体同时阳性患者 ,应用MEIA定量法确证检测HBsAg、抗 HBs、HBeAg、抗 HBe ,应用PCR方法定量检测HBV DNA ,并对患者的临床特点进行综合分析。 结果及结论 ①HBsAg与抗 HBs同时阳性的检出率 2 91% ,检出率最高为重型肝炎 7 4 1% ,其次依次为慢性肝炎 4 90 %、无症状乙肝病毒携带者 2 6 %、肝硬化 1 98%、急性肝炎 0。②无症状感染者、急性肝炎和肝硬变三者合并后的检出率与慢性肝炎、重型肝炎组比较 ,差异具有显著性 (P <0 0 5 )。③HBsAg高滴度组HBV DNA量及阳性率明显高于低滴度组 ,差异具有显著性 (P <0 0 5 )。④抗 HBs值与HBV DNA量间无相关性。

Objective Study the clinical and epidemic characteristics of the patients who have both positive mode of HBsAg and HBsAb. Methods Screening the patients who have both positive mode of HBsAg and HBsAb by applied ELISA,and detecting their HBsAg,HBsAb,HBeAg,HBeAb and HBV-DNA by MEIA and PCR,analysing their clinical characteristics of the patients who have both positive mode of HBsAg and HBsAb. Results and conclusion The rate check out both of the positive mode of HBsAg and HBsAb are 2.91%.The highest rate is fulminant hepatitis (7.41%),the next and one by one in order for is chronic hepatitis (4.90%),hepatitis B virus carrier(2.6%) chronic interstitial hepatitis (1.98%),acute hepatitis (0). There are significance diference in comparison hepatitis B virus carrier,chronic interstitial hepatitis,acute hepatitis with chronic hepatitis,fulminant hepatitis (P<0.05). The quantity of HBV-DNA and positive rate in group of high titer are obvious higher than low titer.There are significance diference (P<0.05). There is not relativity in quantity of HBsAb and HBV-DNA.