黄芪注射液对肾病综合征患者肾小管的保护作用

Protective effects of astragali injection on tubular in patients with primary nephrotic syndrome

目的 :探讨黄芪注射液对原发性肾病综合征 (PNS)患者肾小管的作用及其机制。方法 :6 0例PNS患者随机分成黄芪组 (n =30 )和对照组 (n =30 ) ,观察治疗前后血清白蛋白 (sALB)、2 4h尿蛋白定量 (2 4huP)、尿视黄醇结合蛋白 (uRBP)、尿 β2 微球蛋白 (uβ2 MG)及尿乙酰 β D 氨基葡萄糖苷酶 (uNAG)浓度的变化。结果 :黄芪组治疗后sALB上升 ,uRBP ,uβ2 MG ,uNAG ,2 4huP下降 ,与对照组比较有显著差异 (P <0 .0 1 ,0 .0 5 )。结论

Objective To determine the effects of astragali injection on tubular and its possible mechanisms.Methods Sixty patients with primary nephritic syndrome (PNS) were randomly divided into astragali group( n =30) and control group( n=30). The surm albumin(sALB) and urinary excretion of retinol binding protein(RBP), N Acety β D Glucosaminidase(NAG),β2 Microglobulin( β2MG) were measured before and after the treatment.Results After the one month treatment, sALB was significantly higher,and uβ2MG ,uNAG ,uRBP,and 24 huP were significantly lower in astragali group( P <0.01, P <0.05).Conclusion Astragali injection on tubular plays a protective role in PNS.