氟尿嘧啶对内镜逆行胰胆管造影术后胰腺炎的预防作用

Preventive effect of 5-fluorouracil on post-ERCP pancreatitis

目的 :探讨 5 氟尿嘧啶 (5 FU)对内镜逆行胰胆管造影 (ERCP)术后高淀粉酶血症及急性胰腺炎的预防作用。方法 :将 1 6 0例患者随机分为A组 (5 FU组 ) 80例和B组 (对照组 ) 80例。A组所用造影剂含有 5 FU(76 %泛影葡胺 2 0ml+0 .2 5 % 5 FU生理盐水 30ml) ,B组所用造影剂不含 5 FU(76 %泛影葡胺 2 0ml+生理盐水 30ml) ,术前、术后 6h及 2 4h检测血清淀粉酶。结果 :A组有 9例 (1 1 .2 5 % )和B组有 4 5例 (5 6 .2 5 % )发生高淀粉酶血症 ,两组差异有显著意义 (P <0 .0 1 ) ;A组有 2例 (2 .5 0 % )和B组有 8例 (1 0 .0 0 % )发生急性胰腺炎 ,两组差异有显著意义(P <0 .0 5 )。结论 :5

Objective To investigate the preventive effect of 5 fluorouracil (5 FU) on post ERCP (endoscopic retrograde cholangiopancreatography) hyperamy lasemia and pancreatitis. Methods One hundred and sixty patients who underwent ERCP were divided at random into 2 groups: group A ( n =80) was given meglumine diatrizoate with 5 FU; and group B ( n =80) was used contrast medium without 5 FU. Blood was drawn in each group the day before, 6 hours and 24 hours following ERCP for amylase. Results Post ERCP hyperamylasemia occurred in 9 patients in group A (11.25%) and 45 in B (56.25%) . The difference of both groups was notable. Pancreatitis ensued in 2 instances in group A (2.50%) and 8 in group B (10.00%). Their difference was significant. Conclusion 5 FU added in meglumine diatrizoate is helpful to prevent post ERCP hyperamylasemia and pancreatitis.