摘要
目的:研究福辛普利对自发性高血压大鼠(SHR)终末器官的保护作用。方法:自发性高血压大鼠饲料中给予福辛普利[15 mg(kg·d)]16周,在清醒状态下记录24 h血压波动性,应用光镜和计算机图像分析技术观察心脏和肾脏的组织病理学改变。结果:与SHR相比,福辛普利治疗组大鼠的血压波动性(收缩压、舒张压)明显降低(10.7±1.8vs 16.3±2.1;9.0±1.6vs11.9±1.6),左心室／体质量比、心肌胶原容积分数、肾小球硬化积分与血压波动性呈正相关(0.712,0.686;0.745,0.682;0.651,0.533,P<0.05或P<0.01)。结论:福辛普利长期应用可有效减轻SHR的终末器官损伤。
To study the effects of fosinopril on end-organ damage in spontaneously hypertensive rats(SHR). Methods: Fosinopril[15 mg/(kg · d)] was added in SHR chow for 16 weeks. Blood pressure variability(BPV) was recorded during 24 h in conscious state. Histopathological changes were evaluated with light microscope and computer-assisted image analysis. Results: Long-term treatment with fosinopril significantly decreased BPV (SBPV: 10. 7±1. 8 vs 16. 3±2. 1 mmHg; DBPV: 9. 0±1. 6 vs 11. 9 ± 1. 6 mmHg),and obviously diminished end-organ damage in SHR. The indices of left ventricular and glomerulosclerosis score were all positively related to SBPV and DBPV(0. 712,0. 686; 0. 651,0. 533) in untreated and fos-inopril-treated SHR(P<0. 05,P<0. 01). Conclusion: Fosinopril can obviously protect end-organs in SHR.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2004年第5期469-472,共4页
Academic Journal of Second Military Medical University
基金
ThisworkissupportedbytheNationalNaturalScienceFoundationofChina(30271180).
关键词
福辛普利
自发性高血压
大鼠
终末器官损伤
blood pressure
blood pressure variability
end-organ damage
hypertension
fosinopril
