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p33^(ING1b)在乳腺癌中的研究进展

Research on p33ING1b gene expression in breast carcinoma
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摘要 p33ING1b是由Garkavtsev等采用衰减杂交和体内选择技术分离的一个重要的抑癌基因,它的过表达可有效抑制细胞生长,促进无生长因子条件下的细胞凋亡。在抑制细胞生长过程中,p33ING1b与p53相互依赖,具有协同作用。本文对p33ING1b在乳腺癌中研究的进展作一综述。 p33ING1b, an important tumor suppressor gene, is isolated by Garkavtsev et al with substractive hybridization and subsequent selection of transforming genetic suppressor elements. Its over-expression can effectively inhibit cell growth and promote cell apoptosis. In this process p33ING1b and p53 rely on each other and have synergistic effect. In this article, we reviewed the research progress on p33ING1b gene in breast carcinoma.
作者 章烨 王雅杰 傅强 姜斌 李平 王梅
机构地区 第二军医大学长海医院肿瘤科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2004年第5期541-543,共3页 Academic Journal of Second Military Medical University
关键词 p^33ING1b 乳腺癌 研究进展 抑癌基因 breast neoplasms p33ING16 protein p53 tumor suppressor gene
分类号 R737.9 [医药卫生—肿瘤]
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参考文献21

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二级参考文献11

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第二军医大学学报
2004年 第5期

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