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帕金森病发病机制与路易小体形成关系的研究进展 被引量:1

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摘要 路易小体是帕金森病的重要病理特征,近年来发现路易小体中包含多种成分如α-共核蛋白、parkin及UCH-L1等,在帕金森病发生和发展的不同阶段这些成分具有不同病理特征及生化组成,提示路易小体的形成与帕金森病发病机制密切相关。本文就该方面的研究进展做一文献综述。
出处 《国外医学(老年医学分册)》 2004年第3期99-102,共4页 Foreign Medical Sciences(Geriatrics)
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参考文献25

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同被引文献8

  • 1杜望春,王坚,丁正同,邬剑军,蒋雨平.藻酸钠-多聚赖氨酸-藻酸钠微囊化牛视网膜色素上皮细胞多巴胺分泌特性的研究[J].中华老年医学杂志,2005,24(8):623-626. 被引量:4
  • 2尚庆丽,马景学,王萌,吕兰存,休贺明.两步酶分层消化法用于大鼠视网膜色素上皮细胞的培养[J].眼科研究,2006,24(5):496-499. 被引量:5
  • 3Subramanian T, Marchionini D, Potter EM, et al. Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response. Cell Transplant, 2002, 11:207-214.
  • 4Subramanian T, Bumette B, Miller GW, et al. Characterization of the dopaminergic proerties of human retinal pigmented epithelial ( hRPE ) cells and the effect of intrastriatal transplantation of hRPE cells in hemiparkinsonian (HP) monkeys. Mov Disord, 1998,13:268.
  • 5Watts RL, Raiser CD, Stover NP, et al. Stereotaxic intrastriatal implantation of retinal pigment epithelial cells attached to microcarriers in advanced Parkinson disease (PD) patients: A pilot study in six patients. Parkinsonism Related Disord, 2001,7 (Suppl 87 ) :305.
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  • 7Zhao S, Rizzolo LJ, Barsatable CJ. Diffemtiation and transdifferentiation of the retinalpigment epithelium. Int Rev Cytol, 1997, 171 : 225-266.
  • 8张克忠,王坚,丁正同,余巨明,蒋雨平.蛋白酶体在脑黑质变性和Lewy小体形成中的作用[J].中华老年医学杂志,2004,23(4):259-262. 被引量:7

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