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白介素Ⅱ与老年性骨质疏松

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摘要 本文综述了白介素11对骨形成和骨吸收的作用,及与老年性骨质疏松的关系。
出处 《国外医学(老年医学分册)》 2004年第3期124-127,共4页 Foreign Medical Sciences(Geriatrics)
基金 中央保健委员会专项基金(2002)
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参考文献14

  • 1Kodama Y, Takeuchi Y, Suzawa M et al. Reduced expession of interleukin- 11 in bone marrow stromal cell of senescence- accelerated mice (SAMP6): relationship to osteopenia with enhanced adipogenesis. J Bone Miner Res, 1998; 13(9): 1370~ 1377
  • 2Kuliwaba JS, Findlay DM, Atkins GJ et al. Enhanced expression of osteocalcin mRNA in human osteoarthritic trabecular bone of the proximal femur is associated with decreased expression of interleukin-6 and interleukin-11 mRNA.J Bone Miner Res,2000;15(2):33
  • 3Yanagisawa M, Nakashima K, Arakawa H et al. Astrocyte differentiation of fetal neuroepithelial cells by interleukin- 11via activation of a commpon cytokine signal transducer, gpl30,and a transcription factor, STAT3. J Neurochem, 2000; 74(4): 1498~1504
  • 4O'Brien CA, Gubrij I et al. STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF- KB ligand and stimulation of osteoclastogenesis by gpl30-utilizing cytokines or interleukin- 1 but not 1, 25-Dihydroxyvit
  • 5Tohjima E,Inoue D,Yamamoto N et al.Decreased AP-lactivity and interleukin- 11 expression by bone marrow stromal cells may be associated with impaired bone forrmation in aged mice. J Bone Miner Res, 2003; 18 (8): 1461~1470
  • 6Suga K, Saitoh M, Fukushima S et al. Interleukin- 11 induces osteoblast differentiation and acts synergistically with bone morphogenetic protein- 2 in C3H10T1/2 cells. J Interferon Cytokine Res, 2001; 21 (9): 695~707
  • 7Grotzinger J, Kemebeck T, Kallen KJ et al. IL- 6 type cytokine receptor complexes: hexamer, tetrarmer or both? Biol Chem, 1999; 380:803-813
  • 8Nakchbandi IA, Mitnick MA, Masiukiewicz US et al. IL6 Negatively Regulates IL- 11 Production in Vitro and in Vivo. Endocrinology, 2001; 142 (9): 3850-3856
  • 9Ichioka N, Inaba M, Kushida T et al. Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells. Stem Cells, 2002; 20 (6):542 - 551
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