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非特异性抗精神病药物与糖尿病的关系 被引量：2

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摘要 抗精神病药物是治疗功能性精神病的主要药物,然而在使用这些药物的过程中可能诱导体重增加、糖代谢紊乱、血清瘦素水平升高及胰岛素抵抗。导致体重增加的假设,认为可能通过对H—5HT_(2A)或5—HT_(2C)受体以及组胺H1受体的拮抗引起的。对糖尿病及精神病进行有效控制。
作者 饶小胖 董砚虎
机构地区 青岛市内分泌糖尿病研究所暨医院
出处 《国外医学（老年医学分册）》 2004年第3期135-138,共4页 Foreign Medical Sciences(Geriatrics)
关键词 抗精神病药物 糖尿病 胰岛素抵抗 心理障碍 致病机制
分类号 R587.1 [医药卫生—内分泌]
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参考文献9

  • 1Koro CE, Fedder DO, L' Italien GJ et al. Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case- control study. BMJ, 2002; 325:243～245
  • 2Chue P, Welch R. Investigation of the metabolic effets of antipsychotics in patients with schizophrenia (poster). Presented at the 51st Annual Meeting of the Canadian Psychiatric Association, Quebec, 2001
  • 3Koller EA, Doraiswamy PM. Olanzapine - associateddiabetes mellitus. Pharmacotherapy, 2002; 22:841-852
  • 4Sernyak MJ, Douglas DL, Alarcon RD et al. Assciated diabetes mellitus with se of atypical neuroleptics in the treatment of schizophrenia. Am J Psychiatry, 2002; 15:561-566
  • 5UKPDS Study Group. Characteristics of newly presenting type 2 diabetes patients: male preponderance and obesity at different age. Diabet Med, 1998; 5:154-159
  • 6Dwyer DS, Pinkofsky HB, Liu Y et al. Antipsychotic drugs affect glucose uptake and the express of gluoose transports in PCI12 cells. Prog Neuropsychopharmacol Biol psychiatry,1999; 23:69-80
  • 7Ereshefsky L. Pharmacokinetics and drug interactions: update for new antipsychotics. J Clin Psychiatry, 2002; 57:12-15
  • 8Lund BC, Perry PJ, Brooks J Ⅱ. Clozapine use in patients with schizophrenia and the risk of diabetes、 hyperlipidemia and hypertension: a claims - based approach. 2001; 58 (12):1172- 1176
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同被引文献28

  • 1刘俊彪,吴靖华.氯丙嗪、氯氮平、利培酮对首发精神分裂症患者糖代谢、血脂和体重的影响[J].中国神经精神疾病杂志,2004,30(4):293-295. 被引量：41
  • 2刘素芳,魏平,王世贵,王东平,王云,马慧娟,贾福军.不同剂量氯氮平与精神分裂症患者血脂、血糖代谢的对照研究[J].中华精神科杂志,2005,38(2):82-85. 被引量：31
  • 3Semyak MJ,Leslie DL. Alarcon BD. et al. Association of diabetes metlkus with use of atypical neuroleptics in thetreatment of schizophrenia[ J]. Am J Psychiatry ,2002,159:561-566.
  • 4Wirshing DA, Spellberg B J, Erhart SM, et al. Novel antipsychotics and new onset diabetes[ J]. Bid Psychiatry,1998,4:778-783.
  • 5Casey DE, Zorn SH, The pharmacology of weight gain with antipsyc-hotics[ J]. J Clin Psychiatry 2001,62 : 4-10.
  • 6Lane HY, Chang YC, Chiu CC, et al. Association of risperidone treatment response with a polymorphism in the 5 -HTeA receptor gene[ J ]. Am J Psychiatry,2002,159 : 1593-1595.
  • 7Kmus T, Haack M, Schuld A, et al. Body weisht and leptin plasma levels during treatment with antipsychotic drugs [ J ]. Am J Psychiatry,1999,156:31.
  • 8Hoffstedt J, Eriksson P, Mottagui TS, et al. A polymorphism in the leptin promoter region (-2548 G/A ) influencesgene expression and adipo-se tissue secretion of leptin [ J ]. HormMetab Res,2002, 34 : 355-359.
  • 9Deyer DS, Pinkofsky HB, Liu Yet al. Antipsychotic drugs affect gluccse uptake and the express of gluccess transports in PCI12 cells[J]. Prog Neuropsyc-hopharmacol Biol psychiatry, 1999,23; 69-80.
  • 10Melksson K. uhing AI. Antipsychotic drugs can affect hormone balance, eight gain. lood lipid disturbances and diabetes are important [ J ]. Lakartidninger,2001,8 : 54 -62.

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二级引证文献15

国外医学（老年医学分册）
2004年 第3期

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