小胶质细胞在阿尔茨海默病发病机制中的作用被引量：4

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摘要研究表明,β淀粉样蛋白(amyloid beta-peptide,Aβ)沉积激活小胶质细胞引起的炎症反应是阿尔茨海默病(Akheimer disease,AD)的核心病理机制之一,小胶质细胞在其发病机制中起着重要的作用。小胶质细胞被Ap激活,释放大量细胞因子和炎性介质,促进老年斑(senile plaques,SP)、神经原纤维缠结(neurofibrillary tangles,NFTs)的形成,导致神经元损伤、死亡,促使AD发生、发展。

作者韩笑峰唐荣华王伟

机构地区华中科技大学同济医学院附属同济医院神经内科

出处《国外医学（神经病学．神经外科学分册）》 2004年第2期114-116,共3页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）

基金国家自然科学基金(NO.30230140) 湖北自然科学基金(2001ABB140)

关键词小胶质细胞阿尔茨海默病发病机制 Β淀粉样蛋白炎性介质细胞因子

分类号 R749.16 [医药卫生—神经病学与精神病学]

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