细胞间粘附分子1及其抗体与脑血管痉挛
摘要
SAH后CVS的发生和发展是受痉挛血管周围的血液刺激启动的,这包括血管内皮细胞功能的紊乱。痉挛血管内皮细胞壁上有明显的ICAM-1的上调,且与血管的痉挛程度密切相关。ICAM-1介导白细胞粘附到血管内皮细胞,并透过内皮屏障迁移到组织中。ICAM-1介导的血管壁的炎症反应在SAH后CVS的病理生理过程中起了重要作用,而应用抗ICAM-1单克隆抗体进行治疗可以有效缓解CVS的程度。
出处
《国外医学（神经病学．神经外科学分册）》
2004年第2期197-200,共4页
Foreign Medical Sciences（Section On Neurology & Neurosurgery）
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