期刊文献+

HIV-1整合酶抑制剂的研究进展 被引量:2

下载PDF
导出
摘要 本文介绍了目前正处于临床试验的人类免疫缺陷病毒 1(HIV 1)整合酶抑制剂S 136 0和L 870 810 ;另外 ,主要叙述了近年来发展比较迅速的三大类HIV 1整合酶抑制剂 ,即一般含芳环化合物、寡聚核苷酸和寡聚肽的研究进展。
出处 《国外医学(药学分册)》 2004年第2期65-69,共5页 Foreign Medical Sciences(Section of Pharmarcy)
  • 相关文献

参考文献19

  • 1Abdel-Rahman HM, Al-Karamany GS, El-Koussi NA,et al. HIV protease inhibitors: peptidomimetic drugs and future perspectives[J]. Curr Med Chem, 2002, 9(21):1905- 1922.
  • 2DebyserZ, Cherepanov P, Van Maele B, el. Insearch of authentic inhibitors of HIV-1 integration [J]. Antivir Chem Chemother, 2002, 13(1):1 - 15.
  • 3Zouhiri F, Mouscadet JF, Medkouar K, et al. Structureactivity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1in cell culture[J]. J Med Chem, 2000, 43(8): 1533 -1540.
  • 4Dayam R, Neamati N. Small-molecule HIV-1 integrase inhibitors: the 2001-2002 update [J]. Curr Pharm Des,2003, 9(22): 1789 - 1802.
  • 5Billich A. S-1360 Shionogi-GlaxoSmithKline[J]. Curr Opin Investig Drugs , 2003, 4(2):206-209.
  • 6Boyle BA. Recent developments in HIV research[J]. AIDS Read, 2002,12(9):390-394.
  • 7Marchand C, Zhang X, Pais GC, et al. Structural determinants for HIV-1 integrase inhibition by β-diketo acids[J]. J Biol Chem, 2002, 277(15): 12596- 12603.
  • 8Wai JS, Egbertson MS, Payne LS, et al. 4-Aryl - 2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells[J]. J Med Chem, 2000, 43(26):4923 - 4926.
  • 9Maurin C, Bailly F, Cotelle P. Stucture-activity relationships of HIV-1 integrase inhibitors - enzyme-ligand interactions[J]. Curr Med Chem, 2003, 10(18):1795- 1810.
  • 10Hwang DJ, Kim SN, Choi JH, et al. Dicaffeoyl- or digalloyl pyrrolidine and furan derivatives as HIV integrase inhibitors[J]. Bioorg Med Chem, 2001, 9(6), 1429-1437.

同被引文献33

  • 1周婷,谢蓝.HIV非核苷类逆转录酶抑制剂研究进展[J].药学学报,2004,38(8):666-672. 被引量:17
  • 2裴明军,桂向东,宋礼华.Cyanovirin-N:一种新型灭活HIV-1蛋白的研究进展[J].国外医学(预防.诊断.治疗用生物制品分册),2004,27(5):220-224. 被引量:4
  • 3丁玉兰,赵树进,蒋琳兰,陈晓晖.HIV疫苗的研究进展[J].广东医学,2004,25(11):1342-1344. 被引量:1
  • 4姚勤伟,黄春,吴昊.HIV-1逆转录酶耐核苷类药物突变新进展[J].国外医学(流行病学.传染病学分册),2004,31(6):343-345. 被引量:2
  • 5梁峰,李科,李国秀.HIV-1逆转录酶抑制剂的研究新进展[J].解放军药学学报,2004,20(6):450-453. 被引量:2
  • 6Hazuda D, Felock PJ, Hasings JC, et al. Discovery and analysis of inhibitor of the human immunodeficlency integrase[ J]. Drug Des Discov,1997,15(1):17-24
  • 7Mark R Fesen, Kurt W Kohn, et al. Inhibitors of human immunodeficiency virus integrase [ J ]. Proc. Natl. Acad. Sci.USA, 1993,90:2 399-2 403
  • 8Farnet CM,Wang B,Lipford JR,et al. Differential inhibition of HIV- 1 preintegration complexes and purified integrase protein[J]. Proc Nan Acad Sei USA,1996,93(18) :9 743
  • 9Farnet CM, Wang B, Hansen M, et al. Human immunodeficiency virus type 1 cDNA integration:new aromatic hydroxylated inhibitiors and studies of the inhibitiion mechanism[ J ]. Antimicrob Agents And Chemotherapy, 1998,42 ( 9 ) :2 245
  • 10Markgren PO. Relationships between structure and interaction kinetics for HIV - 1 protease inhibitors [ J ]. J Med Chem,2002,45 (25) :5 430-5 439

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部