阿莫西林钠中甲醇、异丙醇、乙酸甲酯含量测定

Test for Residue Solvent Content in Amoxicillin Sodium Raw Material

目的:建立一种气相色谱法测定原料药阿莫西林钠中甲醇、异丙醇、乙酸甲酯三种有机溶剂残留量。方法:选正丙醇作内标物,在极性弹性石英毛细柱上进行各组分分离,效果良好。柱温:80℃,进样口温度:180℃,检测器温度:250℃。结果:平均回收率甲醇100.0%,并丙醇100.1%,乙酸甲酯100.1%。结论:该方法克服了进样量不准确的缺点,重现性好,精度高。

Objective:To Determine the content of methanol,isopropanol and methylacetate in amoxicillin sodium raw material with the method of gas chromatography method choose n- propanol as the internal standard,and separate each component on a polar elastic quartz capillary column.The effect is well.The oven temperature was set at 80℃,with injector at 180℃ and FID temperature at 250℃,the average recovery was at 100.0%,100.1% and 100.1% for methanol, isopropanol and methylacetate.The results showed that the method is the characters of repro- ducibility and precision.