CD44V6在乳腺癌中的表达及与侵袭、转移的关系

Relationship of CD44V6 expression to invasion and metastasis of breast cancer

[目的 ]探讨乳腺癌细胞CD4 4V6的表达及其与侵袭、转移的关系。 [方法 ]免疫组织化学方法检测 6 0例乳腺癌患者癌组织中CD4 4V6的表达。 [结果 ]CD4 4V6的表达阳性率在中、低分化组分别为 74 .0 7% (2 0 / 2 7)、80 .76 % (2 1 / 2 6 ) ,明显高于高分化组的表达阳性率 4 2 .85 % (3/ 7) (P <0 .0 1 ) ;在淋巴结转移组的表达阳性率为 86 .1 1 % (31 / 36 )明显高于非淋巴结转移组的表达阳性率 5 4.1 6 % (1 3/ 2 4 )(P <0 .0 1 )。 [结论 ]乳腺癌中CD4

Objective] To study the relationship of CD44V6 expression to malignant behaviors of breast cancer. [Methods] The expressions of CD44V6 of 60 breast cancers were detected by immunohistochemical method and the relationship between the expression and pathological factors was analyied. [Results] The expression rates of CD44V6 in the groups of poor and medial differentiation being 80.76%(21/26) and 74.07%(20/27) were significantly higher than that group of well differentiation being 42.85%(3/7)( P <0.01). The expression rate of CD44V6 in the group of lymph node metastases being 86.11%(31/36) was significantly higher than that group of non-lymph node metastases being 54.16%(13/24) ( P <0.01). [Conclusions] The overexpression of CD44V6 may indicate potentiality of invasion and metastasis of breast cancer.