慢性肺心病伴肺脑患者血浆强啡肽含量变化的初步探讨

Study on Changing Content of Plasma Dynorphin in Patients with Chronic Cor Pulmonale with Pulmonecephalopathy

选33例健康人为A组,选27例肺心病为B组和20例肺心病伴肺脑者为C组,测定血浆强啡肽。结果显示:治疗前B、C组血浆强啡肽含量显著高于A组(P<0.001),治疗后B、C组血浆强啡肽明显下降(P<0.001),但仍比A组高(P<0.001)。提示患者血浆强啡肽含量升高与病情严重程度相一致,其含量升高与缺氧、二氧化碳潴留有密切关系。血浆强啡肽具有缺氧性肺脑血管收缩和抑制呼吸的作用。可能参与肺心病的形成有关。

The plasma level of dynorphin were measured in 33 health subjects served as A group and 47 pattents with cor pulmonale pulmonecephalopathy that were divided into two groups: 27 cases of pure cor pulmonale served as B group,20 cases of cor pulmonale with necephalopathy served as C group. The results discovered that the plasma dynorphin in B,C group were more remarkbly raised than A group before treatment (P<0.001 ). After treatment the plasma dynorphin in B, C groups were deopeased remarkbly, but they were higher than A group (P<0.001). The results suggested that increase of the plasma dynorphin in patients with cot pulmonale were concerned with severe degree of disease's condition,it was related to hypoxia,carbon dioxide. Blood vase of lung brain with hypoxia have been contracted by the plasma dynorphin which have depressed respiratory action. Therefor,it could be related to form cor pulmonale.