全野刺激的PRVEP在肝豆状核变性诊断及疗效判断中的作用

Pattern Reversal Visual Evoked Potential of Full-field Stimulation in Hepatolencular Degeneration

对32例肝豆状核变性(HLD)患者治疗前后和30例正常对照组的全野刺激图形反转视觉诱发电位(PRVEP)进行了研究,结果表明:与对照组相比,43.8%治疗前患者全野刺激的PRVEP异常,主要表现为P_(100)波潜伏期延长及其二眼间差增大,前者的延长程度与年龄有关,说明全野刺激的PRVEP检测在HLD的诊断中有辅助价值;14例异常患者治疗后PRVEP与疗前及不同疗效组之间比较,部分变化与疗效有关,因此认为PRVEP可为判断HLD治疗效果提供参考。

Pattern reversal visual evoked potential (PRVEP) of full-field stimulation of 32 patients with hepatolencular degeneration (HLD) before and after treatment and 30 controls (age and sex- matched) were studied. We found that 14 cases (43.8%) of the pre-treated had abnormal PRVEP findings in comparisons with as follows. 1. unilateral or bilateral prolongations of wave P_(100)latency (greater than normal mean plus 3s), 2. abnormal intereye wave P_(100)latency difference, 3. abnormal intereye amplitude ratio of wave P_(100). Comparing with PRVEP before treatment, PRVEP findings from the 14 previously abnormal cases were improved afer treatment. Part of the changes had significant correlation with effects of treatments. The results showed that PRVEP is a useful test in diagnosing HLD and monitoring the therapeutic effect.