苯妥因钠对癫痫患者血清叶酸、Vit B_(12)浓度的影响及其与用药时间的关系

Effect of Diphenylhydontoin on Folic Acid and Vitamin B_(12) of Epileptic Patients and Relation Between the Effect and Treated-Period

采用放射免疫测定方法,对55例单一服用苯妥因钠治疗的癫痫患者及53例正常人进行了血清叶酸、Vit B_(12)浓度测定。根据服药时间,55例患者又分为三组:Ⅰ组为<1年,共21例;Ⅱ组为1～2年,共20例;Ⅲ组为>2年,共14例。结果显示:血清叶酸浓度均值,患者组显著低于对照组,Ⅰ组、Ⅱ组、Ⅲ组逐组降低,各组间差异统计学意义显著;Ⅰ组、Ⅲ组血清叶酸浓度异常发生率显著高于Ⅰ组,说明口服苯妥因钠可降低癫痫患者血清叶酸浓度,用药时间与血清叶酸浓度成反比,与血清叶酸浓度异常发生率成正比。血清Vit B_(12)浓度均值,患者组、Ⅰ组、Ⅱ组、Ⅲ组与对照组无显著差异。

Folic acid and vitamin B_(12)were estimated in serum of fifty-five patients who had only received the usual dose of diphenylhydontoin (DPH) as well as fifty-three normal healthy subjects. The fifty-five patients were divided into group Ⅰ, Ⅱ, Ⅲ that were 1 year, 1-2 years, 2 years of treatedperiod of DPH and had 21, 20, 14 patients individually. On statistical analysis, besides sigoificantly reduced mean values of serum folic acid of the fifty-five patients and group Ⅱ, Ⅲ as compared with fiftythree normal healthy subjects,meanvalues of serum folic acid level were gradually decreased and abnormal rates of serum folic acid level were gradually increased in group Ⅰ, Ⅱ, Ⅲ, that had significantly difference. The result above showed that DPH can significantly reduce the serum folic acid level of epileptic patients and that treated period of DPH was inverse proportion to serum folic acid level and was direct proportion to abnormal rate of serum folic acid level of epileptic patients. Mean values of serum Vitamin B_(12) level had no significantly change in the fifty-five patients and group Ⅰ, Ⅱ, Ⅲ as compared with normal healthy subjects.