雷公藤、干扰素治疗难治性原发性血小板减少性紫癜的临床研究

Oinical Study on Refractory Intractable Primary Thrombocytopenic Purpura with Tripterygium Wilfordii and Inferon

目的观察雷公藤联合干扰素治疗特发性难治性血小板减少性紫癜的临床疗效。方法对18例原发性血小板减少性紫癜(ITP))患者用雷公藤联合干扰素治疗,干扰素剂量:体重<50kg者200万U/次,H,每周2次;体重≥50kg者,300U/次,H,每周3次,4周1疗程;雷公藤多甙片1mg/kg·d。对照组给予强的松30mg/m^2·d,观察比较其疗效和血小板相关IgG)、相关IgA。结果治疗组总有效率83.3％,而对照组总有效率为60.7％,两者比较有显著差异(P<0.05),治疗组的血小板相关IgG与对照组相比有显著差异(P<0.05)。结论对于特发性难治性血小板减少性紫癜患者,用雷公藤联合干扰素治疗效果明显。

Objective To observe the effect of Glucosidorum tripterygii tororum (GTT) and r IFNa-2 b on refractory idiopathic thrombo-cytopenic purpura (IUTP).Methods 18 cases with refractory idiopathic tlironibocytopenic purpura were treated with γ-IFN a-2b (200-300U/t,H) and GTT tablet (Img/kg d) while 15 cases of control group treated with meticorten for 2 onths,and effective rate and PAIgG and PAIgA Were determined after treatment.Results The effective rate of treatment group is 83.3% while that of control group is 60.7% ,and the PAIgG of treatment group is different apparently from control group.Conclusion GTT and r IFNa-2b lias apparent effect on refractory idiopathic thrombocytopenic purpura.