盐酸加替沙星对感染性疾病治疗评价

Clinical study of gatifloxacin in the treatment of bacterial infections

目的:探讨盐酸加替沙星对细菌感染性疾病的抗菌作用及安全性。方法:用随机对照平行实验设计法对未接受其它抗生素治疗的58例呼吸、泌尿道感染患者分别给予加替沙星、左氧氟沙星治疗,评价其临床疗效、安全性和抗菌作用。结果:①加替沙星治疗组和左氧氟沙星治疗组临床有效率分别为89.3％和96.4％,细菌分离阳性率、菌株产酶率、细菌清除率分别为85.94％和90.63％、76.47％和76.78％、89.3％和96.4％。无显著性差异(P>0.05)。两组均未发现严重不良反应。②体外抗菌活性试验中加替沙星对革兰阳性菌的抗菌活性优于左氧氟沙星,两组药物对革兰阴性菌均具有良好的抗菌活性。结论:加替沙星的抗菌谱和临床疗效与左氧氟沙星相似,对革兰阳性菌的抗菌活性优于后者,有较好的临床应用价值。

Objective:To study the antibacterial activity and evaluate the clinical efficacy and safety of gatifloxacin. Methods : A randomized controlled clinical trial on efficacy and bactericidal activity of gatifloxacin was used in the Respiratory tract infections and Urinary tract infections. Results:(1) There was no statistical significant difference in clinical efficacy between gatifloxacin group(89. 3% ) and Levofloxacin ( 96.4% ) ,P =0. 6110. There were no serious adverse drug reactions. (2) The results showed that the strains isolated rate, β-lactamase produced rate and the bacterial clearance rate of the two groups were 85. 94% and 90. 63% ,76.47% and 76.78% ,89. 3% and 96. 4% no statistical significance (P >0. 05) . (3)The antibacterial activity in vitro of gatifloxacin against gram positive strains was better than evofloxacin. Gatifloxacin and evofloxacin had almost similar antibacterial activity against Enterobacter bacteria. Conclusion: The antibacterial spectrum and clinical efficacy of gatifloxacin was similar to levofloxacin and the antibiotic activity against gram positive strains was better than levofloxacin.