颅脑损伤后白细胞变化的临床意义

Clinical significance of leukocyte after the injury to brain

目的 探讨白细胞变化在颅脑损伤后继发性脑损害中的作用。方法 随机选取伤后 2 4h内入院的颅脑损伤患者 2 4例 (实验组 ) ,对照组选取同期于我院进行体检健康者 12例。实验组按照入院时格拉斯哥昏迷评分法(GCS)评分及预后 (GOS)分组 ,在入院时、2 4h、4 8h、96h不同时间段采集血标本 ,同时进行GCS评分 ,采用我院Beckman Coulter(HMX ,America)自动血液分析仪进行白细胞计数及分类 ,计数中性粒细胞。结果 颅脑损伤后2 4h内白细胞明显升高且达高峰 ,中性粒细胞在 4 8h达高峰 ,伤后 96h较对照组仍高。不同时间段白细胞与对照组有统计学意义 (P <0 .0 5 )。GCS≤ 8分组白细胞计数显著高于GCS >8分组 (P <0 .0 5 ) ;预后不良组白细胞计数显著高于预后良好组 (P <0 .0 5 )。结论 白细胞在颅脑损伤后继发性脑损害中起重要作用 ,颅脑损伤后白细胞明显升高 ,且与损伤程度及预后密切相关。

Objective To investigate the function of leckocyte in the delayed brain injury.Methods 24 patients admitted to the hospital within 24 hours were randomly selected and 12 healthy men having physical examination were also selected as the control.Blood samples were taken on admission, 24 h,48 h and 96 h after injury.Leukocytes and Polymorphonuclear neutrophil cells(PMN) were counted with Beckman-Coulter(HMX,America).Results Leukocyte count increased significantly and reached the peak after 24h post-injury. Leukocyte count was significantly related to the GCS(P<0.01)and neurological outcome(P<0.01).Conclusion Leukocyte increases significantly after brain injury.The count of leukocyte is correlated with the severity of the injury scaled by GCS and with neurological outcome .