1999/2002年医院感染细菌的流行病学调查

Epidemiological study on pathogenic bacteria in the nosocomial infection from 1999 to 2002

目的 :了解医院感染致病菌菌谱及耐药性动态变化 ,为临床经验性治疗细菌感染性疾病提供依据 .方法 :药敏试验用K B纸片法 ,根据NCCLS标准判断结果 ,应用WHONET 5软件对临床分离细菌的药敏结果进行统计 .结果 :1 999/ 2 0 0 2年医院感染的致病菌以G 杆菌为主 ,对所监测的 1 6种抗菌药物均不同程度耐药 ;耐甲氧西林金黄色葡萄球菌 (methicillin resistantStaphylococcusaureus,MRSA) ,耐甲氧西林表皮葡萄球菌 (methicillin resistantStaphylococcusepi dermidis,MRSE) ,和产超广谱 β内酰胺酶 (extended spec trumbeta lactamases,ESBLs)细菌耐药率明显增加 ,MRSA ,MRSE和产ESBLs细菌的比例及耐药性均无明显变化 .结论 :MRSA ,MRSE和产ESBLs细菌耐药率明显增加的情况 。

AIM: To investigate the dynamic changes in the distribution and resistance of bacilli responsible for the nosocomial infection and to offer a basis for the empirical treatment of bacterial infection. METHODS: K B test was used for the antibiotics susceptivity test and the results were recorded based on National Committee for Clinical Laboratory Standards (NCCLS) and analyzed with WHONET 5 software. RESULTS: The pathogens responsible for the nosocomial infection were mainly Gram negative bacteria during the 4 years from 1999 to 2002. They were resistant to 16 kinds of studied antibiotics. The resistant rate of methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE) and extended spectrum beta lactamases (ESBLs) producing strains markedly increased, but there were no obvious changes in the distribution and resistance of those pathogens mentioned above. CONCLUSION: The resistant rate of MSRA,MSRE and ESBLs-producing bacilli has increased markedly.