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成年大鼠海马p-CREB的分布 被引量：5

Distribution of p-CREB in hippocampal formation of adult rats
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摘要 目的 :观察磷酸化CREB(p CREB)在正常成年大鼠海马结构的表达 .方法 :在多聚甲醛固定的海马脑薄片上 ,用免疫组化SP法和免疫荧光法观察 p CREB在正常成年大鼠海马结构的表达与分布 .结果 :p CREB在正常大鼠海马结构有广泛表达 ,在齿状回表达最强 ,CA3区次之 ,CA1区最弱 .阳性表达主要位于胞核 .结论 :p CREB在海马结构齿状回和CA1区的表达是不同的 .由于CREB参与某些形式的长期记忆 ,本结果提示齿状回和海马CA1区可能在长期记忆中的作用不同 . AIM: To investigate the expression and distribution of p CREB in the hippocampal formation of adult rats. METHODS: SP immunohistochemical staining and immunofluorescence were performed in paraformaldehyde fixed hippocampal sections. RESULTS: p CREB was expressed throughout the hippocampal formation, with the expression in the dentate gyrus being the highest, CA3 area, the second, and CA1 area, the least. P CREB was also found to have expressed mostly in nucleus. CONCLUSION: The expressions of p CREB are different in the dentate gyrus and CA1 area, suggesting that dentate gyrus and CA1 area may play different roles in long-term memory.
作者 于玮 张莉 韩太真 蒋马莉
机构地区 西安交通大学医学院生理学教研室
出处 《第四军医大学学报》 CAS 北大核心 2004年第10期874-876,共3页 Journal of the Fourth Military Medical University
基金 国家自然科学基金资助项目 (30 1 70 31 0 ) 西安交通大学重点培植基金资助项目 (1 60 0 82 0 0 3)
关键词 CREB 海马 免疫组织化学 免疫荧光法 CREB hippocampus immunohistochemistry immunofluorescence
分类号 R338 [医药卫生—人体生理学]
  • 相关文献

参考文献6

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二级参考文献6

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共引文献5

同被引文献41

  • 1于晓军,赵福弟,刘卯阳,王兆辰,吴家馼.大鼠脑震荡模型的建立及病理学研究[J].法医学杂志,1992,8(3):119-123. 被引量：21
  • 2吕奔,唐怡庭,谷蔚琼,陈富周,李有秋,罗学港,雷德亮.雌激素对全脑缺血再灌小鼠海马CA_1区P-CREB和BDNF表达的影响[J].神经解剖学杂志,2005,21(4):401-404. 被引量：6
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引证文献5

二级引证文献34

第四军医大学学报
2004年 第10期

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