盐酸多西环素精制结晶工艺的改进

Improvement of crystallization process of Doxycycline Hydrochloride

目的 考察多西环素精制结晶工艺条件。方法 用氯化氢 -乙醇代替CP盐酸进行精制结晶。结果 使用氯化氢 -乙醇代替CP盐酸可得到合格的盐酸多西环素结晶。结论 多西环素结晶时以氯化氢 -乙醇代替CP盐酸,质量易于控制。

Objective Crystallization process of Doxycycline Hydrochloride was studied.Methods HCl-CH 3CH 2OH was used in crystallization instead of Hydrochloric acid.Results Qualified Doxycycline Hydrochloride was obtained using HCI-CH 3CH 2OH instead of Hydrochloric acid.Conclusion Using HCl-CH 3CH 2OH instead of Hydrochloric acid can easily improve the quality of Doxycycline Hydrochloride during crystallization,especially to control black mixtures.