黄芪注射液对慢性肾炎气虚血瘀证大鼠模型的药效学研究

Pharmacodynamic Study of Radix Astragali Injection for Rat Chronic Glomerulonephritis with Qi-Deficiency and Blood-Stasis

【目的】观察黄芪注射液对大鼠慢性肾炎气虚血瘀证模型的治疗作用。【方法】SD大鼠 4 8只 ,除 12只作空白对照组外 ,其他大鼠均在慢性肾炎模型的基础上加造气虚血瘀证模型后 ,随机分为模型组、黄芪高剂量组 (8g/kg)和黄芪低剂量组 (4g/kg) ,每组 12只 ;给药 4周后 ,检测模型大鼠的一般状态、肾功能、细胞免疫功能及肾组织病理学改变 ,进行组间疗效比较。【结果】黄芪高、低剂量组对模型大鼠的一般状态、生化指标及肾组织的病理损害均有改善作用 ,并呈现出剂量效应关系。【结论】黄芪注射液能提高慢性肾炎气虚血瘀证大鼠的细胞免疫功能 ,改善血凝状态 ,减轻肾组织病理损害 ,有防治慢性肾炎的作用。

To explore the therapeutic mechanism of Radix Astragali Injection (RAI) on rat chronic glomerulonephritis with Qi-deficiency and blood-stasis.Rat chronic glomerulonephritis models with Qi-deficiency and blood-stasis were randomized to model group (A), high-dose RAI group (B) and low-dose RAI group (C) and other 12 normal rats served as blank control(D). After a 4-week treatment, therapeutic effects in various groups were compared. The changes of general state, biochemical parameters and pathological lesion of renal tissues in groups B and C were improved in a dose-effect manner.[Conclusion]RAI is effective in treating and preventing chronic glomerulonephritis with Qi-deficiency and blood-stasis by improving cellular immune function and blood coagulation and by relieving pathological lesion of renal tissues.