体位改变对兔油酸型ARDS模型肺CT的影响

Effect of body position changes on lung CT image in rabbits with oleic acid induced acute respiratory distress syndrome

目的 国外近几年对急性呼吸窘迫综合征 (acuterespiratorydistresssyndrome,ARDS)肺进行CT研究后 ,发现病肺存在“重力依赖区” ,该文通过动物实验探讨ARDS发生时肺CT的变化以及体位变化对其的影响。方法 复制油酸型ARDS兔动物模型 ,模型制作成功后 ,随机分组将兔置于不同体位 ,然后进行螺旋CT肺扫描 ,分析不同体位下不同肺区CT值的变化。结果 ARDS时兔肺呈明显的重力依赖效应 ,体位的变化对肺CT的影响非常迅速 ,连续旋转后兔肺重力依赖作用减轻。结论 ARDS时出现重力压迫性肺不张 ,旋转体位能减轻压迫性肺不张的程度。

Objective In recent years, oversea researchers have found there are “dependent regions” in acute respiratory distress syndrome (ARDS) lung computed tomography (CT). This study aims to explore the changes of lung CT image in rabbits with oleic acid induced ARDS and the effect of body position changes on CT image. Methods The model of rabbit ARDS was induced using oleic acid. The rabbits with ARDS all underwent lung spiral CT scans and were divided into six groups according to the body position of scans. Results Lung CT showed a dependent region and non-dependent region, and the image alteration of two regions was induced by the change of the body position. The gravitational effect was reduced after continuous rotation of body position at an equal speed. Conclusions The continuous rotation of body position can relieve the severity of compressive lung collapse in ARDS.