大剂量X线头部照射对三种模型大鼠垂体内分泌功能的影响

Influence of head irradiation with large dose X-rays on pituitary endocrine function in 3 model male rats

本文报道,去胸腺雄性大鼠血清PRL、TSH和GH水平明显降低,而去肾上腺雄性大鼠这3种激素水平有不同程度增高,去睾丸大鼠仅血清PRL水平明显增高。三种动物模型经10GyX射线头部照射后48h,去胸腺和去肾上腺大鼠3种激素水平都有降低趋势,而去睾丸大鼠却略有增加。上述结果提示,3种大鼠模型种经内分泌调节功能已发生异常改变,不能产生正常大鼠头部照射后下丘脑-垂体功能的增强效应。

The present study reported that serum PRL. TSH and GH levels were all lowered obviously in thymectomized rats, while the above three hormone levels in serum increased in different degrees in the adrenalectomized male rats, and only serum PRL level increased in the testectomized rats. Forty eight hours after head irradiation with 10 Gy X-rays, these three hormone levels in serum all tended to reduce in the thymectomized and the adrenalectomized rats, but slightly increased in the testectomized rats. These results suggest that changes in the normal neuroendocrine regulatory func-tionin three model rats probably prevented the effect of functional enhancement as seen after head irradiation in normal male rats.