疯油膏对豚鼠皮肤苔藓样变模型的影响

THE EFFECT OF CHINESE TRADITIONAL MEDICINE FENG OINIMENT ON THE GUINEA PIG MODEL OF LICHENIFICATION

本文通过DNCB诱导变应性接触性皮炎,局部反复激发来建立动物皮肤苔藓样变的模型将模型用於观察中药疯油膏、氯氟舒松霜及单纯凡士林外用使皮损消退时间。结果疯油膏组为9±1.41天,氯氟舒松霜组为1O.5±1.87天,对照组为21±1.79天,疯油膏与对照组相比,有显著性差异(P<O.01),与氯氟舒松霜相比,无明显差异(P>0.05),因此疯油膏的作用可与氯氟舒松霜相媲美。

The Guinea pig model of lichenification was established by DNCB inducing allergic contact dermatitis and rcpeadly challenging on the same part of skin. The time of lichenification disappearance after painting Feng ointment,Halcinonid cream and vaseline was calculated. It was 9 ±1.41 days in Feng ointment group vs 10.5 ± 1.87 days in Halcinonid cream group and 21 ± 1.79 days in vaseline (control) group. Feng ointment group was compared with control group, and it was found that the difference was very significant (P<0.01). but not when compared with Halcinonid cream group (P>0.05) . The authors believe that the effectiveness of Feng ointment is as good as that of Halcinonid cream .