钩端螺旋体病神经系统病变的发病机理与治疗探讨(附105例临床分析)

MECHANISM AND TREATMENT RESEARCH ABOUT NERVOUS SYSTEM DISEASE OF LEPTOSPIROSIS

本文报道105例钩端螺旋体病神经系统病变,认为本病的发生可能为钩端螺旋体或钩端螺旋体L型直接损伤了神经组织或供血血管,引发变态反应致间质性炎症病理改变及内毒素等病理作用。甲硝哒唑易透过血脑屏障,能损伤钩体DNA,其疗效优于青霉素,可减少钩端螺旋体病神经系统后发症。

This paper has reported 105 cases about nervous system disease of leptospirosis. The authors consider that leptospira or leptospira L-form can directly damage nervous tissue or supplied blood vessel,and therefore lead to messechymalitis pathological change of allergy and pathological action of endotoxin. Metranidazale is easy to pass through blood-brain barrier and can damage leptospiral DNA.The effect is better than penicillin. It may reduce sequelae of leptospirosis nervous system.