慢性肺心病急发期血液流变学改变对肝循环的影响

EFFECTS OF HEMORHEOLOGIC CHANGES ON HEPATIC CIRCULATION IN COR PULMONALE

本文对肺心病28例、正常组20名测定肝血流量(HBF)、肝动脉血流量(HABF)、门静脉血流量(PVBF)以及全血比粘度高切值、低切值、红细胞压积.结果表明:肺心病组HBF、PVBF与全血比粘度高切值呈负相关(r=-0.6025,P<0.001;r=-0.5698,P<0.002),与低切值及红细胞压积无相关性.肺心病急发期因缺氧及酸中毒使红细胞变形能力降低,致肝脏血流灌注减少,尤其是门静脉血流的影响更为重要.

This paper has studied hepatic blood flow(HBF) ,hepatic arterial blood flow(HASF), venae portal blood flow(PVBF) and hemorheologic parameters in 28 patients with cor pulmonale and 20 normal subjects . The findings revealed that HBF and PVBF were negatively related with blood viscosity and Ht(r=- 0. 6025,P<0. 001,and r=-0. 5698,P<0. 002,respectively)but not with hemotocrit and Lt. The deteriorated red cell deformability resulting from hypoxia and acido-sis may cause decreasse in the hepatic blood perfusion, especially in the venae portal blood flow.