硝苯啶对慢性肺心病肺内分流的影响

INFLUENCE OF NIFEDIPINE ON PULMONARY RIGHT TO LEFT SHUNTS IN CHRONIC COR PULMONALE

本文对31例慢性肺心病急性发作期患者,随机分为治疗组(A组)17例和对照组(B组)14例.于治疗前和治疗后一周末分别检测肺内分流率(Qs/Qt)、全肺V_A及动脉血气分析.结果示A组较B组以Qs/Qt明显下降(P<0.05),PaO_2、V_(50)、V_(25)明显上升(P<0.05),全肺V_A/Q无显著改变(P>0.05).研究表明硝苯啶能有效地抑制缺氧性肺血管收缩和支气管平滑肌痉挛,使Qs/Qt降低,PaO_2上升,没有导致V_A/Q的恶化。

Thirty-one patients with cor pulmonale during acute exacerbation were randomly divided into the following two groups: treatment group(group A,17 cases)and control group(group B,14 cases). Before and one week after the experiment,pulmonary right to left shunt(Qs/Qt), VA/Q and arterial blood gases were determined in all the cases. The results showed that decrease of Qs/Qt in group A was larger than that in group B, associated with significant increases in PaO2,V50 and V25(P<0. 05)but no change in VA/Q(P>0. 05). It is concluded that nifedipine can effectively suppress hypoxic pulmonary vascular constriction and bronchial muscular spasm so that Qs/Qt is decreased and PaO2 increased,not accompanied with variations in VA/Q.