抗CEA单克隆抗体对卵巢癌放射免疫显像研究

RADIOIMMUNOIMAGING IN OVARIAN CANCER WITH MURINE MONOCLONAL ANTIBODY AGAINST CARCINOEMBRYONIC ANTIGEN

用^(131)I-抗CEA单克隆抗体对22例卵巢癌患者进行放射免疫显像研究,结果20例阳性显像,2例阴性显像(假阴性),20例阳性者结果与手术中所见相符,48处转移灶共发现45处,阳性率93.8％,最小检出病灶直径1.5cm,其中2例大网膜广泛转移和1例升结肠转移为采用本方法首次发现,显示放射免疫显像对卵巢癌不仅可以定性定位,还能检出转移灶,与B超、CT等方法比较具有一定优点,有较好的临床应用价值.

Twenty-two cases of ovarian cancer with operatively and histologically proven were studied by radioimmunoimaging (RID, using anti-CEA monoclonal antibody radiolabeled with 131I. Positive results were obtained in 20/22 of the ovarian cancer patients. No correlation between serum CEA and RII results was found. Forty-five of 48 metastatic lesions were localized with a positive rate of 93. 8%. Two ovarian cancer metastasis to omentum and one ovarian cancer metastasis to ascending colon were detected only by RII. The results have confirmed the advantages of RII over CT and ultrasonography.