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表遗传修饰与配子形成和胚胎早期发育 被引量：2

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摘要 DNA甲基化/去甲基化及组蛋白的共价修饰是主要的表遗传修饰(epigenetic reprogramming)方式。在配子形成和早期胚胎发育中,其与基因组印记(genomic imprinting)、染色质结构重组(chro-matin remodeling)、X-染色体失活(X-inactivation)的形成均有密切关系,它们的共同作用机制是调节基因的表达。表遗传修饰至少发生在两个关键时期——配子形成期和植入前胚胎,如果在此期间发生异常,则会导致胚胎的死亡及生后各种疾病的发生。
作者 赵冬梅 金帆 黄荷凤
机构地区 %浙江大学医学院附属妇产科医院 浙江大学医学院附属妇产科医院
出处 《国外医学（遗传学分册）》 2004年第3期159-162,共4页 Foreign Medical Sciences(Section of Genetics )
关键词 表遗传修饰 配子形成 胚胎 早期发育 DNA甲基化 组蛋白乙酰化
分类号 Q75 [生物学—分子生物学]
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参考文献26

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共引文献24

同被引文献52

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国外医学（遗传学分册）
2004年 第3期

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