树突状细胞肿瘤疫苗的制备及临床应用面临的问题

Preparation of Dendritic Cell Tumor-Vaccine with Dendritic Cells and Problems in Its Clinical Uses —— Review

树突状细胞 (DC)是目前发现的功能最强的抗原呈递细胞 ,其在肿瘤免疫临床治疗中的应用受到越来越多的关注。目前 ,通过各种方法提取肿瘤抗原来冲击致敏DC ,再将已培养成熟的DC回输到病人体内 ,以激发机体产生明确的抗肿瘤免疫应答 ,已成为有效的临床抗肿瘤治疗手段 ,也为肿瘤临床继手术切除、放化疗及其它综合治疗后又开辟了一个新的治疗途径。本文就DC的生物学特性、体外培养及其临床应用作一综述。

Dendritic cell (DC),the most powerful antigen presenting cell,has been paid close attention to tumor immunotherapy. The tumor antigens were extracted by different ways to pulse DC,and then the muture DC were infused to patients to accelerate anti-tumor immuno responses. Its clinical use would provide a new therapeutic pathway other than surgical operation,irradiation,chemotherapy. In this paper,biological characteristics of DC,tumor-vaccine preparation and its clinical use were reviewed.