氟伐他汀对老年人颈动脉粥样斑块的影响

Effect of fluvastatin on carotid atherosclerotic plaques in elderly patients

目的 观察氟伐他汀对老年人颈动脉粥样斑块的影响。方法 对 5 5例颈动脉斑块的老年患者给予氟伐他汀 (来适可 ) 2 0mg,每日 1次 ,治疗 6个月 ,观察其对患者血脂各项指标 (TC、TG、LDL C、HDL C)的影响 ,并通过颈动脉彩色超声检查观察患者颈动脉内径、血流阻力、血流速度及动脉斑块积分的变化。结果 氟伐他汀治疗 6个月后 ,TC、LDL C均下降 ,HDL C升高 (P <0 .0 5 ) ,而TG无明显变化。颈动脉斑块积分明显减小 ,颈动脉内径增加 ,阻力指数减小 ,与治疗前比较有统计学意义 (P<0 .0 5或P <0 .0 1) ,而血流速度则无明显变化。结论 氟伐他汀对老年人患者的颈动脉斑块有稳定和消退作用。

Objective To observe the effect of fluvastatin on carotid atherosclerotic plaques in elderly patients.Methods 55 elderly patients with carotid atherosclerosis received fluvastatin (lescol) 20 mg orally,once a day,for 6 months.The effects of fluvastatin on the patients' blood fat parameters including TC,TG,LDL-C and HDL-C were observed,and the changes of artery bore,blood flow resistance,blood flow velocity and artery plaque score were observed by carotid color ultrasonic examination.Results 6 months after treatment with lescol,TC and LDL-C were decreased,HDL-C was increased (P<0.05),the area of plaques became smaller,carotid bore was increased,resistant index was reduced.There were significant differences before treatemnt and after traetmenrt (P<0.05 or P< 0.01 ). There was no obvious change in blood flow velocity. Conclusion Fluvastatin is effective in treating carotid atherosclerosis plaques in elderly patients.