通心络胶囊对急性脑梗死患者临床与脑血流影响

Clinical efficacy of Tongxinluo capsule and the effect on cerebral blood flow in patients with acute cerebral infarction

目的 观察通心络胶囊对急性脑梗死治疗效果及对患者脑血流的影响。方法 选择 90例急性脑梗死患者随机分为 2组 ,通心络胶囊加常规药物治疗组 (治疗组 ) 4 5例 ,常规药物治疗组 (对照组 ) 4 5例。观察 2组患者治疗后有效率、治疗前后神经功能缺损评分及脑血流变化。结果 治疗组总有效率为 86 .7% ,明显优于对照组的 73.3% (P <0 .0 5 )。治疗后 2组神经功能缺损评分均较治疗前有明显降低 (均为P <0 .0 1) ,但治疗组 (8.4 2± 2 .2 8)下降明显优于对照组 (12 .4 5± 2 .6 4 ) ,有非常显著性差异(P <0 .0 1) ;治疗后 2组脑血管搏动指数和血管阻力指数明显改善 (P <0 .0 1) ,但治疗组改善更为明显 ,与对照组比较有显著性差异 (P <0 .0 5 )。 2组均未出现明显副作用。结论 通心络胶囊治疗急性脑梗死可明显提高临床疗效 ,改善脑血流量 ,且用药是安全的。

Objective To observe the therapeutic effect of Tongxinluo capsule on acute cerebral infarction and the effect on the patients' cerebral blood flow.Methods 90 patients with acute cerebral infarction were randomly divided into two groups.45 patients in treatment group were treated by Tongxinluo capsule combined with routine medicines;the other 45 patients were treated by routine medicines only. The effective rate after treatnment,the change of cerebral blood flow and neurological impairment score were observed for both groups.Results The total effective rate was 86.7% in treatment group,which was obviously superior to that(73.3%) in control group (P<0.05). The neurological impairment score after treatment was(8.42±2.45),which was also significantly superior to that (12.45±2.64) in control group.The vascular pulsation index and vascular resistance index were significantly improved after treatment for both groups(P<0.01),however,the improvement was more obvious in treatment group than that in control group (P<0.05).Conclusion Tongxinluo capsule can increase the therapeutic effect on acute cerebral infarction,which can improve cerebral blood flow,with safe administration.