玻璃基生物骨水泥内部纳米羟基磷灰石的形成研究

Research on the formation of nano-size hydroxyapatite in glass based bone cement

以CaO SiO2 P2O5系统生物玻璃和磷酸铵调和液混合制得玻璃基生物骨水泥(GBC),利用XRD、FTIR和SEM对GBC的产物晶相、化学组成和内部显微结构进行了分析,并对其力学性能进行了测试。实验结果表明,随着浸泡时间的增加GBC中的玻璃相逐步向羟基磷灰石(HAP)微晶转化,生成的磷灰石为弱结晶度的类骨状碳酸羟基磷灰石微晶,这些微晶主要分布于玻璃粉末的界面之间,端面尺寸在30～50nm,这表明GBC中所生成的HAP晶体与人体骨有很大的相似性,因而会具有良好的生物活性。对力学性能测试的结果表明,随着浸泡时间的增加GBC的抗压强度逐步增加,在30天时可达到80MPa。因而GBC不仅具有良好的生物活性,而且具有一定的力学强度。

Glass based bone cement (GBC) was synthesized by mixing CaO-SiO2-P2O5 based glass powder with ammonium phosphate liquid. Phase compositions, chemical compositions and microstructure of the final products of GBC were measured and observed using X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy respectively. The experimental results show that with a longer immersion time in simulated body fluid the glass phase in GBC gradually changes to hydroxyapatite. The crystal formed in GBC belongs to a bone-like hydroxya-carbonate apatite crystallite with the end plane granularity of 30-50 nm. Mechanical testing results show that the compressive strength of GBC increases with the proceeding of immersion in simulated body fluid, reaching 80 MPa after 30 days. It is evident that GBC is a desirable biomedical material for the repairing of bone defects with excellent biocompability and high mechanical strength.