颈动脉粥样硬化与冠心病关系的研究

The study of relationship between the carotid atheroscalerosis and coronary artery disease

目的 探讨颈动脉粥样硬化与冠心病之间的关系。方法 采用高频超声对 72例因急性心肌梗死、心绞痛及胸痛待查而入院接受冠状动脉造影的病人进行颈动脉检查 ,根据冠状动脉造影结果分为正常冠状动脉组(A组 )和冠状动脉病变组 (分别为单支病变组B1、双支病变组B2、三支病变组B3) ,采用高频超声探测双侧颈总动脉、颈内动脉及颈外动脉 ,计算颈动脉斑块积分 ,测量血管后壁内中膜厚度 (IMT)及颈动脉内血流频谱Vmax。结果 冠状动脉病变组的IMT值明显高于冠状动脉正常组 (P <0 0 5 ) ,冠状动脉三支病变组的IMT值高于单支和双支病变组 (P<0 0 5 ) ,提示颈动脉的病变与冠状动脉病变之间有良好的相关性 (r=0 4 5 ,P <0 0 5 ) ,且外周动脉粥样硬化的程度与冠状动脉病变的程度密切相关。结论 通过对颈动脉的超声检测 ,可以早期发现冠状动脉的病变 。

Objective To evaluate the relationship between the carotid atheroscalerosis and coronary artery disease. Methods High frequency ultrasonography was used to examine the carotid artery in seventy two patients who had undergone coronary artery angiography because of acute myocardiac infarction, angina or chest pain. They were divided a group with normal coronary angiography and another group with coronary artery lesion. The latter group included three subgroups according to the number of coronary artery involved: B1 group, B2 group, and B3 group. Scoring of atherosclerosis of the common carotid artery, internal carotid artery and external carotid artery were made with reference to plaques, the intima media thickness (IMT) and the V max of blood flow of the carotid artery as demonstrated by high frequency ultrasonograply. Results The IMT of the group with coronary lesion was significantly higher than that of the normal group ( P <0 05), and the IMT of the subgroup with three blood vessel lesion (B3 group) was significantly different from that of the subgroup with one blood vessel lesion (B1 group) ( P <0 05). The observation suggested that there was good correlation between carotid artery lesion and coronary artery lesion ( r =0 45, P <0 05). Conclusion The coronary artery lesion can be predicted by examining the carotid artery by ultrasonography