理气复胃口服液治疗气滞食积型功能性消化不良临床研究

Clinical Effect of Liqifuwei Liquid on Patients with Functional Dyspepsia due to Stagnation of Qi and Retention of Food

目的:观察理气复胃口服液对气滞食积型功能性消化不良(FD)的临床疗效及安全性。方法:采用双盲双模拟法,将60例气滞食积型FD患者随机分为治疗组和对照组各30例,分别采用理气复胃口服液和莫沙比利治疗,疗程4周。观察治疗后临床症状积分值、核素胃排空率和安全性指标的变化。结果:治疗组总有效率96.7％,对照组为96.3％,两组比较差异无统计学意义。治疗组治疗后核素胃排空率明显升高(P<0.05)。两组治疗后血、尿及粪常规,肝肾功能,心电图检查均无异常。结论:理气复胃口服液能明显改善气滞食积型FD患者的临床症状,提高核素胃排空率,安全有效,疗效与莫沙比利相当。

To observe clinical effect of Liqituwei liquid(LL) on the patients with functional dyspepsia(FD) due to stagnation of qi and retention of food and its security. Methods: Sixty cases of patients with FD due to stagnation of qi and retention of food were randomly divided into treatment group(n=30) and control group(n=30),which were treated by LL and Mosapride tablet respectively. The treatment course was 28 days. Changes of symptoms scores of FD due to stagnation of qi and retention of food,stomach emptying rate of 99n Tc and index of security were observed. Results: Total effective rate was 96.7% in treatment group and 96.3% in control group. Stomach emptying rate of 99m Tc in treatment group was increased significantly after the treatment (P<0.05). Security index of the two groups were normal after treatment. Conclusion: LL can improve significantly the clinical symptoms in patients with FD due to stagnation of qi and retention of food, increase stomach emptying rate of 99mTc with security and effectiveness. The clinical effect of LL is similar to that of Mosapride.