急性出血性脑血管病中医辨证分型与血浆胃动素水平观察

Relationship between TCM Differentiation of Symptoms and Signs of Acute Hemorrhagic Cerebrovascular Disease and Motilin

目的:探讨血浆胃动素(MTL)变化与急性出血性脑血管病中医辨证分型的关系。方法:应用放射免疫测定法分别测定171例急性出血性脑血管病患者和50例对照者入院后翌日、排便后翌日、病程第7天及第14天的血浆MTL浓度,并分别进行组间比较。结果:急性出血性脑血管病组的4次血浆MTL含量均较对照组有所升高(P<0.05);且其各中医证型中痰热腑实、风痰火亢、风痰瘀阻型和痰湿蒙神型的血浆MTL水平较对照组显著升高(P<0.01),随着病情好转MTL水平逐渐降低。结论:急性出血性脑血管病中医的辨证分型,特别是痰热腑实等证型的确定及通腑药的合理应用,为临床提供一个客观指标,将充实和完善脑卒中的辨治理论。

To explore the relationship between the level of plasma motilin(MTL) and TCM differentiation of symptoms and signs of acute hemor(?)hagic cerebrovascular diseas. Methods:Radioimmunoassay was applied to test the concentration of plasma MTL of 171 patients with acute hemorrhagic cerebrovascular disease and 50 normal control on the second day after entering hospital, on the second day after defecation, on the seventh day and the fourteenth day of the disease course. The levels among the groups were compared respectively. Results: The concentration of MTL in patients with acute hemorrhagic cerebrovascular disease was higher than that of the control group(P<0.05) In acute hemorrhagic cerebrovascular disease, the level of MTL in phlegm-heat and Fu excess syndrome, excess of wind-phlegm-fire syndrome, accumulation of wind-phlegm syndrome and vitality confused by phlegm-dampness syndrome was obviously higher(P<0.01). The level of MTL was lowered with the improving of the disease. Conclusion: This article initiatively proposes an objective index in reasonably applying laxatives and purgatives to cure acute hemorrhagic cerebrovascular disease, especially in phlegm-heat and Fu excess syndrome. The research is likely to richen and complete the theory of TCM.