妊娠合并梅毒及胎儿结局

Analysis of syphilis in pregnancy and its outcome

目的 探讨妊娠合并梅毒及胎儿结局。方法 根据妊娠期是否行抗梅毒治疗 ,将 3 7例经血清学检查确诊为梅毒的孕妇分为两组 :治疗组 2 1例 ,普鲁卡因青霉素G 80万U肌注 ,每日一次 ,连续 15天为一疗程。未治疗组16例 ,未行抗梅毒治疗。比较两组孕妇的妊娠结局。结果 ( 1)一期梅毒 1例 ,隐性梅毒 3 6例。 ( 2 )治疗组孕妇早产 1例 ,无流产发生 ;未治疗组早产 5例 ,流产 5例 ,两组比较差异有显著性 (p <0 .0 5 )。治疗组孕妇新生儿先天梅毒2例 ,未治疗组新生儿先天梅毒 6例 ,两组比较差异有显著性 (p <0 .0 5 )。结论 ( 1)妊娠合并梅毒患者以隐性梅毒为主 ,对孕妇行常规梅毒筛查非常重要。 ( 2 )妊娠合并梅毒患者在妊娠期行抗梅毒治疗能很好地控制早产、流产 。

Objective To investigate obstetric treatment and pregnant outcome of syphilis infection during pregnancy.Methods 37 pregnant women diagnosed with syphilis by serological assays were divided into treated group and untreated group according to whether they accepted treatment against syphilis .Patients in the treated group accepted Procainpenicillin G 0.8 million unit once daily intramuscular injection or Erythromycin 0.5g four times daily if they were allergic to penicillin for two weeks.The pregnant outcome was observed and compared between the two groups.Results There were 1 case of primary syphilis,36 cases were latent syphilis. The occurrence of premature birth?abortion were 1?0, and 2 cases of congenital syphilis in total 21 cases who carried pregnancy to term in the treated group;while 5?5,6 in the untreated group respectively.Conclusions Pregnant syphilis is prone to be misdiagnosed because of its slight symptom, so it is especially important to screen syphilis as routine among pregnant women.Premature?abortion?congenital syphilis can be well controlled through regular treatment during pregnancy.