福辛普利对慢性心力衰竭血清白细胞介素-6的影响

Effects of fosinopril on serum level of interleukin-6 in patients with chronic heart failure

目的 探讨老年慢性心力衰竭 (CHF)患者血清白细胞介素 6(IL 6)的变化及福辛普利对其影响。 方法 采用双抗体夹心ELISA法检测 3 1例老年CHF患者及 18例健康者血清IL 6水平 ,并将老年CHF患者分为常规治疗组 ( 14例 )和常规治疗 +福辛普利治疗组 ( 17例 )共观察 3周。 结果 ①老年CHF患者血清IL 6水平显著高于对照组 (P <0 0 1) ,且与左室射血分数 (LVEF)呈负相关 (r =-0 5 5 ,P <0 0 5 ) ;②经 3周治疗后福辛普利组患者IL 6水平明显降低 (P <0 0 5 ) ,且伴有心率明显下降 (P <0 0 5 )和LVEF明显增高 (P <0 0 5 )。 结论 老年CHF患者存在IL 6水平明显增高 ,并与左室收缩功能呈负相关 ,福辛普利可降低血清IL 6水平有益于老年CHF患者心功能改善。

Objective To study the effects of fosinopril on serum interleukin-6(IL-6) in the elderly with chronic heart failure(CHF). Methods Serum IL-6 in 31 elderly patients with chronic heart failure and 18 elderly healthy controls were investigated by enzyme-linked immunosorbent assay.The elderly patients with CHF were randomized to receive routine therapy(routine group,n=14)or fosinopril in addition to routine therapy(fosinopril group,n=17)for 3 weeks.Evaluations were made before and after treatment. Results ①Levels of IL-6 in the elderly CHF patients were significantly higher than those in the controls,and the serum level of IL-6 was negatively related to left ventricular ejection fraction(LVEF)(r=-0.55,P<0.01).②After treatment,the level of IL-6 decreased in fosinopril group(P<0.05),with lowered heart rates and increased LVEF(P<0.05). Conclusions Elevated IL-6 levels are present in elderly patient with CHF.Fosinopril treatment can decrease the IL-6 levels in elderly patients with CHF,which may play an important role in improving of the function of the left ventricle.