可溶性细胞间粘附分子在慢性肾脏病中的变化

Change of Soluable intercellular adhesion molecule in the chrouie Kidney disease

目的:研究慢性肾病(CKD)患者血清可溶性细胞粘附分子-1(soluble intercellular adhesionmolecule-1,sICAM)的变化与临床意义。方法:用双抗体夹心ELISA方法,对52例CKD患者及20例健康对照人群的sICAM-1水平进行检测分析。52例CKD患者中,其中27例为CRF血液透析患者;25例肾功能正常CKD患者。结果:CKD组患者sICAM-1水平明显高于对照组(105.42±61.95)(P<0.01);肾功能正常CKD组和CKD-CRF组sICAM-1水平均显著高于对照组(P<0.01);CRF组sICAM-1水平明显低于肾功能正常CKD组(P<0.01);但高于对照组(84.80±19.61/164.08±70.66/54.61±5.48)(P<0.01)。结论:sICAM-1水平在慢性肾脏病中明显升高,CRF组病人sICAM-1水平低于CKD肾功能正常患者,提示透析过程中可能有sICAM溢出,吸附并丢失入透析液中(1),或可能是肾纤维化为主的病变使sICAM-1表达下降。

Objective:To study the value of soluble intercellular adhesion molecule - 1(sICAM-1)in the patients who suffered from chronic kidney diseases(CKD) .Methods: We measured the level of sICAM-1 by ELISA in 52 patients with CKD and 20 normal person for control. In the patients group, 27 with hemodialysis because of CRP, and another 25 without renal failure.Results: The level of sICAM-1 were significantly higher in the CKD group than the control group(p < 0.01). sICAM-1 were significandy higher in CKD with or without CRP than in the control group ( p < 0.01). sICAM-1 were significantly lower in CKD with CRP thanin CKD without renal failure (p < 0.01). Conclusions:sICAM-l showed a significant increase in CKD, and sICAM-lwere lower in CKD with CRP than in CKD without renal failure may suggest that sICAM-1 can be overflowed or absorbed and be lost in the dialysis liquid.