用Heck反应合成1-羟基-4-(3-吡啶基)丁-2-酮

Synthesis of 1-Hydroxy-4-(3-pyridyl)butan-2-one Using Heck Reaction

在Heck反应条件下 ,以Ph3 P为催化剂配体 ,由 3 卤代吡啶和 3 丁烯 1,2 二醇进行偶合可以得到 1 羟基 4 ( 3 吡啶基 )丁 2 酮 ,具有原料易得。

Under the Heck reaction condition with Ph3P as ligand, 1-hydroxy-4-(3-pyridyl)butan-2-one can be synthesized utilizing cross-coupling of 3-halopyridine and 3-butene-1,2-diol, and this methodology has the advantage of lower cost and wider diversity of raw material.