氨基酸嵌段聚醚氨酯的合成及其膜表面共价肝素化修饰

Synthesis of Amino-acid Segmented Polyetherurethane and Its Film Modified by Heparin

以L-赖氨酸甲酯和L-膀胱氨酸二甲酯分别作扩链剂进行嵌段聚醚氨酯的合成并将产物制成透明薄膜。为了进一步改进膜的抗凝血性,在膜的表面以酰胺共价键结合天然肝素进行修饰。实验结果表明所得膜表面在扫描电镜观察下呈凹凸不平的结构形态,其抗凝血性有显著提高,而膜仍保持优良弹性。测定了SPEU膜的其它性能。

SPEU-Ⅰ,Ⅱ were novel antithrombogenic polyetherurethane materials. They were synthesized by the segmented polyetherurethane (SPEU) with L-Lysine methyl ester (L-Lys-OMe) and L-Cystine dimethyl ester (L-Cys-diOMe) as extenders.Heparin is covalently bounded on the SPEU film surface which can improve the antithrombosis of film. The experimental results showed that both SPEU-Ⅰ and SPEU-Ⅱ products with the yields above 90%. Their IR, dynamic mechanical properties and anticoagulant activities were measured.Both SPEU-Ⅰ and SPEU-Ⅱ have good blood compatibility and their morphological research results by the scanning electron microscopy photographs of the grafted films.After graft copolymerized with heparine, the SPEU films become opaque and the scanning electron micrographs clearly showed surface graft copolymerization of the films.