产超广谱β-内酰胺酶大肠埃希菌的耐药性分析

Analysis of antibiotic resistance of extended-spectrum β-lactamases Esherichia coli

目的 :了解产超广谱 β 内酰胺酶大肠埃希菌在泌尿系统感染中的流行情况及对 12种常用抗菌药物的耐药性 ,为临床合理使用抗生素提供必要依据。方法 :采用K B纸片扩散法 ,测定 12 8株大肠埃希菌对 12种抗菌药物的耐药性 ,同时使用E test方法筛选超广谱 β 内酰胺酶阳性菌株。 结果 :从 12 8株大肠埃希菌中共检出ESBL 2 6株 ,产ESBL细菌阳性率为 2 0 3%。在 12种抗菌药物中 ,亚胺培南的体外抗菌活性最好 ,敏感率为 10 0 % ,其次为阿米卡星 (90 5 % )。结论 :产ESBL细菌多重耐药现象严重 ,只有正确使用抗生素才能降低ESBL的发生 ,而对于产ESBL菌株感染的治疗 ,亚胺培南应作为首选药物。

Objective: To understand the epidemic of the extend-spectrum β-lactamases E.coli in the urinary system infection and it's resistance to 12 antibiotics so as to provide necessary grounds to the clinical practice.Methods:The antibiotic resistance of 128 E.coli to 12 antibiotics was detected by using K-B scraps methods.The positive case with the extend-spectrum β-lactamases was screened by E-test.Results:26 producing ESBL bacterias was deteced in 128 E·coli .It's positive rate was 20.3%.The best effect of killing bacteria was imipenem in vitro .It's susceptibility was 100%,secondly was Amikcacin(90.5%).Conclusion:The multidrug resistance was serious in the producing ESBL bacterias.The occerance of the produing ESBL bacterias could be reduced by using antibiotics.Imipenem shoule be applied firstly in the treatment to the infection of the producing ESBL bacterias.