新的手性膦配体的合成及其在苯乙烯不对称氢甲酰化反应中的应用

Synthesis of new chiral phosphine ligands and their applications in the asymmetric hydroformylation of styrene

以甘露醇为原料合成了两个新的手性膦配体 ,并用这些新的手性膦配体和醋酸钯原位生成的催化剂体系催化苯乙烯的不对称氢甲酰化反应 ,当配体为手性膦氧配体 (DDPPIO)时得到S构型的 2 苯基丙醛的e .e .为 2 1 9% ,用手性膦硫配体 (DDPPIS)作配体时得到S构型的 2 苯基丙醛的e .e .1 1 2 %。

Two new chiral phosphine ligands,1,4;3,6 dianhydro 2,5 O dideoxy 2,5 bis (diphenyl phosphinoxy) L iditol;1,4;3,6 dianhydro 2,5 O dideoxy 2,5 bis(diphenyl phosphinsulphur) L iditol,have been prepared from D mannitol in four steps.Palladium catalytic systems formed with these ligands in situ were used as asymmetric homogeneous catalysts for hydroformylation of styrene,giving( S ) 2 phenyl propionaldehyde in 21.9%and 11.2%e.e.value respectively.