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2β-甲酯基-3β-(4-氟苯基)去甲基托烷的合成 被引量：1

Synthesis of 2β-carbomethoxy-3β-(4-fluorophenyl)nortropane
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摘要 以可卡因为原料 ,经水解、脱水、甲酯化、4 氟苯基溴化镁格氏反应、脱N 甲基等反应制备 2 β 甲酯基 3β (4 氟苯基 )托烷 (WIN35 ,4 2 8;β CFT)及 2 β 甲酯基 3β (4 氟苯基 )去甲基托烷 (nor β CFT)。化合物的结构经红外光谱、紫外光谱。 Carbomethoxy 3 β (4 fluorophenyl)nortropane(nor β CFT)and 2 β carbomethoxy 3 β (4 fluorophenyl)tropane(WIN35,428; β CFT)were prepared from cocaine by hydrolysis,dehydration,esterification,Grignard reaction and N demethylation.The structures of the two compounds were confirmed by IR,UV and MS spectra.
作者 李晓敏 陈正平 傅榕赓 张同兴 王颂佩
机构地区 江苏省原子医学研究所
出处 《化学试剂》 CAS CSCD 北大核心 2004年第3期185-186,共2页 Chemical Reagents
基金 国家"十五"科技攻关项目 ( 2 0 0 1BA70 2B0 2 ) 江苏省卫生厅重点科研项目 (H2 0 0 8) 江苏省社会发展指导性计划 (BS2 0 0 3 612 )
关键词 可卡因衍生物 WIN35 428 nor-β-CFT 合成 cocaine derivatives WIN35,428 nor-β-CFT Synthesis
分类号 O621.3 [理学—有机化学]
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参考文献7

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同被引文献13

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  • 6Chen ZP,Wang SP,Li XM,et al.A one-step automated high-radiochemical-yield synthesis of ^18F-FECNT from mesylate precursor.Appl Radiat Isot,2008,26.1881-1885.
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化学试剂
2004年 第3期

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