类风湿关节炎的肺功能改变

Pulmonary manifestation in rheumatoid arthritis

目的 探讨类风湿关节炎 (RA)的肺功能改变情况。方法 采用肺功能检查仪检测 2 0例RA患者及2 0例健康成人的肺功能。结果 1 9例患者有肺功能改变 ,弥散功能 (DLCO)为 (78.70± 1 3.0 2 )ml·kPa-1 ·s-1 ,最大自主通气量 (MVV)为 (95 .6 0± 2 0 .5 1 )L ,与对照组的 (1 1 6 .80± 2 2 .5 6 )和 (1 2 5 .90± 2 1 .94 )L比较降低 ,P <0 .0 1 ;用力呼吸 1秒率 (FEV1 /FVC)为 (77.4 5± 5 .83)L ,与对照组比较显著降低 (P <0 .0 5 ) ;残气容量 /肺总量比(RV/TLC)为 31 .85± 7.4 7,显著升高。结论 RA的肺功能改变以弥散功能障碍为主 ,其次为通气功能障碍 。

Objective To evaluate the changes of lung function in patients with rheumatoid artnritis.Methods The lung function of 20 RA patients and 20 normal subjects was tested respectively.Results Of the 20 RA patients,19 showed lung function impairment.The carbon monoxide(DLCO) diffusion capacity and maximal voluntary ventilation(MVV) were decreased compared with normal subjects.The difference was significant( P <0.01).First scond forced expiratory ratio (FEV 1/FVC) was reduced and the residual volume/total lung capacity (RV/TLC) ratio was increased ( P < 0.05 ).Conclusions The most characteristic lung function change in RA patients is the decrease of diffuse capacity.In addition,the decrease of ventilation capacity and emphysema can also be found.