妊娠早、中期生殖道B族链球菌带菌情况研究

Colonization of group B streptococci in early and midterm pregnancy

目的 分析妊娠早、中期妇女生殖道B族链球菌 (GBS)的带菌状况 ,探讨GBS引起宫内感染的时间、途径和可能导致感染的相关因素。方法 对 1 2 2例妊娠早期妇女生殖道分泌物、宫腔内吸出物和 1 2 4例妊娠中期妇女生殖道分泌物、羊水及部分胎盘子面、胎儿肺脏表面及心室腔内拭子进行GBS培养。结果 妊娠早期妇女生殖道GBS带菌率为 1 1 .4 % ;妊娠中期妇女生殖道GBS带菌率为 8.5 7% ,羊水培养全部为阴性 ;2 0例妊娠中期流产的胎盘子面、胎儿肺脏及心脏试子GBS培养均为阴性 ,其中包括 4例生殖道分泌物GBS阳性者 ;在各种相关因素中 ,生殖道 pH值增高、念珠菌性阴道炎等在GBS阳性组的出现率稍高于GBS阴性组 ,但无显著性差异。 结论 部分妊娠妇女生殖道携带GBS ,但无明显特殊表现。如无诱因GBS在妊娠中期尚不能逆行直接侵入羊膜腔引起宫内感染。

Objective To evaluate the materinal colonization of group B streptococcus in early or midterm pregnancy,and explore the time,the way and the risk factors that cause intrauterine infection.Methods The vaginal samples from 122 women in early pregnancy and 124 women in midterm pregnancy were collected.Other samples were taken from other sites (including uterine cavity,amniotic fluid and placenta,etc).Results The results showed that the GBS carrier rate was 11.4% and 8.57% in early and midterm pregnancy respectively.Candidal vaginitis and high vaginal pH were probably associated with GBS infection.Conclusions Part of pregnant women were colonized with GBS.