益肾活血方对家兔血瘀模型纤溶系统作用的实验研究

Study on function of decoction for invigorating the kidney and improving blood circulation on rabbits blood stasis model

目的 :探讨益肾活血药对家兔血瘀模型纤溶系统的作用。方法 :兔 30只 ,随机分为健康组、模型组、益肾活血方大剂量组和小剂量组、血栓宁组 ,各组相应处理后分别取静脉血检测组织型纤溶酶原激活剂 (t PA)、纤溶酶原激活剂抑制物 (PAI)、纤维蛋白原 (Fbg)、D 二聚体 (DD)。每组随机取一只内脏作病理检查。结果 :t PA ,PAI,Fbg,DD ,健康组与模型组比P <0 .0 1,大、小剂量组、血栓宁组与模型组比P <0 .0 5 ,大、小剂量组与血栓宁组比P <0 .0 5 ,大剂量组与小剂量组比P >0 .0 5。病理改变模型组较重 ,血栓宁组次之 ,大、小剂量组较轻 ,健康组无异常变化。结论 :造模成功 ,大、小剂量组及血栓宁组对血瘀模型纤溶系统均有作用 ;大、小剂量组强于血栓宁组。病理改变符合血液检测变化。

Objective: To evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbits blood stasis model. Method: Thirty rabbits were ramdomly divided into normal group, model group, heavy dose group, slight dose group and Xue Shuan Ning group. Tissue-typ eplasminogen activator (t-PA), plasminogen activator inhibitor (PAI), fibrinogen (Fbg) and D-dimer (DD) were investigated after those rabbits had been treated. One was selected randomly from each group to observe pathological changes. Result: There was significant difference in t-PA, PAI, Fbg and DD between normal group and other groups ( P <0.01). Among groups of heavy dose, slight dose, Xue Shuan Ning and model, the statistical differences were significant, as well as among groups of heavy dose, slight dose and Xue Shuan Ning ( P <0.05). However,there was no statistical difference between heavy dose group and slight dose group ( P >0.05). The pathological changes in model group were most serious, and those in Xue Shuan Ning were less serious. There were slight pathological change in heavy dose group and light dose group. Conclusion: Models were made successfully. Heavy dose group and slight dose group have stronger effect on thrombosis than Xue Shuan Ning group.